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Link: https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase
Description: Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO 2.This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming ...
Link: https://en.wikipedia.org/wiki/IDH1
Description: Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.These enzymes belong to two distinct subclasses, one of which uses NAD + as the electron acceptor and the other NADP +.Five isocitrate dehydrogenases have been reported: three NAD ...
Link: https://www.ncbi.nlm.nih.gov/gene/3417
Description: Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered to be frequent and highly conserved in secondary glioblastoma multiforme and lower-grade gliomas. IDH1/2 and DNMT3A mutation status was independent of GADD45A hyper-methylation in predicting acute myeloid leukemia survival. IDH1 mutation is associated with glioma.
Link: https://medlineplus.gov/genetics/gene/idh1/
Description: The IDH1 gene provides instructions for making an enzyme called isocitrate dehydrogenase 1. This enzyme is primarily found in the fluid-filled space inside cells (the cytoplasm). It is also found in cellular structures called peroxisomes, which are small sacs within cells that process many types of molecules. Learn about this gene and related health conditions.
Link: https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Datasheet/10/i5036dat.pdf
Description: Isocitrate dehydrogenase (NADP+) [EC 1.1.1.42] is a Krebs cycle enzyme, which converts isocitrate to α-ketoglutarate. The flow of isocitrate through the glyoxylate bypass is regulated by phosphorylation of isocitrate dehydrogenase, which competes for a common substrate (isocitrate) with isocitrate lyase.1
Link: https://www.sciencedirect.com/science/article/pii/S0300908420303114
Description: 1. Introduction. Isocitrate dehydrogenase (IDH) is a critical enzyme in the tricarboxylic acid (TCA) cycle that catalyzes the reversible oxidative decarboxylation of isocitrate to α-oxoglutarate (α-KG) and CO 2 along with the reduction of NAD(P) + to NAD(P)H. IDHs are widely distributed among all organisms and have evolved into three types (type I IDH, type II IDH and monomeric IDH ...
Link: https://www.omim.org/entry/147700
Description: IDH1 is a dimeric cytosolic NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) that catalyzes decarboxylation of isocitrate into alpha-ketoglutarate (Nekrutenko et al., 1998). Cloning and Expression
Link: https://www.sciencedirect.com/topics/neuroscience/isocitrate-dehydrogenase
Description: Isocitrate dehydrogenase (IDH) is an enzyme that is best known from its role in the Krebs cycle, catalyzing the oxidative decarboxylation of isocitrate, resulting in alpha-ketoglutarate and carbon dioxide. The isoforms IDH1 and IDH2 encode a cytosolic and a mitochondrial protein, respectively.
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