Description: Isocitrate dehydrogenase and is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2. This is a two-step process, which involves oxidation of isocitrate to oxalosuccinate, followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and I
Description: Isocitrate dehydrogenase (ICDH) is a citric acid or tricarboxylic acid cycle enzyme. Isocitrate undergoes dehydrogenation in the presence of ICDH to form oxalosuccinate. In mammalian tissues, there are two NADP-specific ICDH isoenzymes located in the mitochondria and cytoplasm respectively.
Description: Isocitrate dehydrogenase performs the third reaction in the citric acid cycle, which releases one of the carbon atoms as carbon dioxide. In the process, two hydrogens are also removed. One of these, in the form of a hydride, is transferred to the carrier NAD (or NADP), and will be used later to power the rotation of ATP synthase.
Description: Isocitrate dehydrogenase (IDH) is an important enzyme in the tricarboxylic acid cycle, which occurs in the mitochondrial matrix. IDH is responsible for catalyzing the reversible conversion of isocitrate to alpha-ketoglutarate and CO 2 in a two-step reaction . The first step of the reaction involves the oxidation of isocitrate to the intermediate oxalosuccinate.
Description: Isocitrate dehydrogenases are enzymes which catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate (α-ketoglutarate). This reaction also produces NADPH (IDH1 and IDH2) or NADH (IDH3) 4,5. Isocitrate dehydrogenase acts at the rate-limiting step of the tricarboxylic acid (TCA; Krebs) cycle.
Description: i·so·cit·rate de·hy·dro·gen·ase one of two enzymes that catalyze the conversion of threo-ds-isocitrate, the product of the action of both aconitase and isocitrate lyase, to α-ketoglutarate (2-oxoglutarate) and CO2; one of the isozymes uses NAD+ (participating in the tricarboxylic acid cycle), whereas the other uses NADP+. Synonym(s): isocitric ...
Description: In metabolism: Energy state of the cell Some forms of isocitrate dehydrogenase are maximally active only in the presence of ADP or AMP and are inhibited by ATP. This is an example of regulation by covalent modification of an enzyme since the action of ATP here is to phosphorylate, and consequently to inactivate, the isocitrate…
Description: Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which uses NAD + as the electron acceptor and the other NADP +.
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