Description: Oral antibiotic prophylaxis reduces spontaneous bacterial peritonitis occurrence and improves short-term survival in cirrhosis: a meta-analysis. Am J Gastroenterol 2009; 104:993. Loomba R, Wesley R, Bain A, et al. Role of fluoroquinolones in the primary prophylaxis of spontaneous bacterial peritonitis: meta-analysis.
Description: According to investigators, approximately 2.5% of all hospitalizations in patients with liver cirrhosis are due to spontaneous bacterial peritonitis. Based on the findings of the review, there is very low-certainty evidence concerning antibiotic prophylaxis.
Description: Spontaneous bacterial peritonitis (SBP), an infection of ascites caused by translocation of bacteria from the intestinal lumen into the systemic circulation, is a frequent event and a common cause of death in patients with cirrhosis.1, 2 In some patients the mechanism of death is an uncontrolled infection and septic shock. More commonly, however, the infection is cured with antibiotics but ...
Description: WASHINGTON – Patients with cirrhosis who received secondary prophylaxis for spontaneous bacterial peritonitis had better outcomes than patients who received primary prophylaxis in a review of more than 300 patients at 14 North American centers. The mortality rate during follow-up of cirrhotic patients hospitalized while on primary prophylaxis against spontaneous bacterial peritonitis (SBP ...
Description: To review the literature regarding long-term prophylaxis of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis. DATA SOURCES: A MEDLINE (1967–September 2004) and bibliographic search of the English-language literature was conducted using the search terms spontaneous bacterial peritonitis, cirrhosis, antimicrobial, and prophylaxis.
Description: Spontaneous Bacterial Peritonitis (SBP) is a frequent and serious complication of cirrhotic patients with ascites. If your patient has liver cirrhosis, alcohol excess or alcoholic liver disease AND clinical ascites or shifting dullness or a fluid thrill present SBP should be suspected. Investigations
Description: SBP.(1,4) However, in the absence of additional risk factors, incidence of SBP is relatively low ( 20% at 1 TABLE 1. Current Indications of Antibiotic Prophylaxis in Cirrhosis* Indication Antibiotic and Dose Duration Secondary prophylaxis Norﬂoxacin 400 mg/day or ciproﬂoxacin 500 mg/day PO Until liver transplantation or death
Description: DISCUSSION: In this inpatient cirrhosis study, despite prophylaxis, a high proportion of patients developed SBP, which was associated with mortality. Cirrhotic inpatients on 1° prophylaxis had worse outcomes than those on 2° prophylaxis when propensity-matched for the MELD score and serum albumin during the index admission and 90-day follow-up.
Description: SBP is a significant cause of morbidity and mortality in patients with cirrhosis, with the mortality rate approaching 20% to 40%.2 Of the 32% to 34% of cirrhotic patients who present with, or develop, a bacterial infection during their hospitalization, 25% are due to SBP. 1 Changes in gut motility, mucosal defense, and microflora allow for ...
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