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Description: 6.1.2 Adjuvant. Adjuvants are the chemical substances that induce or enhance the antigen specific immune response without precipitating any toxicity. The rationale for selection of adjuvant depends on factors, such as the type of antigen, nature of immune response, and route of vaccination.
Description: Adjuvants are agents or drugs that have few or no antigenic effects or properties but may have the potential to increase the efficacy or potency of vaccines or other drugs when given at the same time (see Chapter 9). Some of the most common adjuvants used in vaccine preparations are aluminum salts and monophosphoryl lipid (MPL)/QS21 cocktails.
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Description: Adjuvants with direct cytotoxic effects. In this issue of the JCI, Besch et al. report that introduction of viral RNA mimetics into human melanoma cells can stimulate a novel signal transduction pathway that triggers activation of the mitochondrial pathway of apoptosis, culminating in melanoma cell death.
Description: Adjuvants are used in many vaccines, but their mechanisms of action are not fully understood. Studies from the past decade on adjuvant mechanisms are slowly revealing the secrets of adjuvant activity. In this review, we have summarized the recent progress in our understanding of the mechanisms of ...
Description: “I think the thing that’s given success in this area of adjuvants, is having such a direct input from the grower and what their needs are,” he says, explaining that ideas and suggestions from Helena staff and customers out in the field carry serious weight in the company’s product development process.
Description: Furthermore, it is now admitted that Alum, like many other adjuvants, acts by direct activation of the immune cells. In mice, Alum induces a profoundly polarized Th2 immune response which is characterized by the production of IL-4 and IL-5 and the strong induction of antibodies production as immunoglobulin IgE and IgG1 [12-13]. Consequently ...
Description: Drift Control Agent and Deposition Aid Drift retardants can be a valuable tool to reduce the risk of off-target pesticide movement. While many options and premix formulations have been developed over the years, few are as cost effective and easy to use as DIRECT™ RS. DIRECT RS chemically modiﬁ...
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