Description: Furthermore, these four diseases share a similar complex of signs and symptoms which further support a common denominator.Thus, we review herein the current data regarding the role of adjuvants in the pathogenesis of immune mediated diseases as well as the amassed data regarding each of these four conditions.
Description: Autoimmune/inflammatory syndrome induced by adjuvants, also known as Shoenfeld's syndrome or ASIA, is a theoretical autoimmune disorder proposed by Israeli immunologist Yehuda Shoenfeld in 2011. According to Shoenfeld, the syndrome includes four conditions: "post-vaccination symptoms," macrophagic myofasciitis, Gulf war syndrome, sick building syndrome, and siliconosis.
Description: Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA) is a relatively new entity introduced in 2011. Diagnosis of ASIA is based on major and minor criteria encompassing generalized signs and symptoms such as persistent fatigue, cognitive difficulties, neurological deficits, myalgias/arthralgias, and dry mouth. As the name implies, an immune adjuvant is requisite,
Description: Future studies that could help clarify the association between vaccinations, adjuvants and autoimmunity should ideally have a different design, more long-term data and should include autoimmune phenomena as well as large-scale epidemiological studies of autoimmune diseases.
Description: The activation of the immune system by adjuvants, a desirable effect, could trigger manifestations of autoimmunity or autoimmune disease. Recently, a new syndrome was introduced, autoimmune/inflammatory syndrome induced by adjuvants (ASIA), that includes postvaccination phenomena, macrophagic myofasciitis, Gulf War syndrome and siliconosis.
Description: These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the ...
Description: Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel. Incumbent of the Laura Schwarz‐Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel ... Some adjuvants may exert adverse effects upon injection, or on the other hand, may not trigger a full ...
Description: adjuvants, ASIA, Autoimmune inflammatory syndrome induced adjuvants, Hyaluronic acid, immunogenesis, inflammation, schonfelds syndrome ... That is, there is a direct correlation between the severity of autoimmune diseases of connective tissue and the content of antibodies to glucosamine .
Description: Luisa Eca Guimarares Session 14: 4th International Symposium on Vaccines in Leipzig, Germany April, 2016 Thank you for watching! For more information and exclusive content visit us at www.cmsri.org.
Description: The very fact that TLR activation leads to adaptive immune responses to foreign entities explains why so many adjuvants used today in vaccinations are developed to mimic TLR ligands. Alongside their supportive role, adjuvants were found to inflict by themselves an illness of autoimmune nature, defined as ‘the adjuvant diseases’.
Copyright © 2017